Opal Key Resort & Marina is located on Front Street in Old Town Key West, just a few minutes’ walk from waterfront Mallory Square and the Mel Fisher Maritime Museum, which displays a collection of shipwreck treasures.

The hotel is located within the cruise ship port in an historic building, and provides direct access to the Key West marina. They also offer a shuttle service across the city.

There is an outdoor swimming pool, access to a nearby spa and three unique waterfront restaurants for dining. These include a casual bistro, Bistro 245, the poolside Castaways and Sunset Deck – a tranquil spot for enjoying fresh pressed margaritas as the sun goes down. This hotel is one of the most suitable family-friendly venues in Key West for those travelling to the area with children.

Marquesa Hotel

Painted a beautiful shade of turquoise, the boutique Marquesa Hotel is nestled in the historic centre of Key West, housed in a former grocery store.

This luxury property is almost as well known as the famous Café Marquesa restaurant, located onsite and often rated as the best restaurant in Key West. It’s open for breakfast and dinner, serving a delectable selection of island favorites.

The Marquesa Hotel features three swimming pools, lush tropical gardens and well-appointed rooms that tastefully blend the modern with the traditional. Duval Street and the Audubon House are within walking distance of this property.

Sunset Key Cottages

Get away from it all at an exclusive experience on a private island. Sunset Key is a 27-acre private island just off the north coast of Key West, accessible by ferry.

It is home to the fabulous adults-only Sunset Key Cottages, a series of luxury cottage rentals that take over the entire island. Nestled among bougainvillea and swaying palm trees, the collection of one-, two-, three- and four-bedroom cottages all feature sweeping ocean views, private verandas, modern furnishings, and are designed in traditional Key West style.

Amenities include an onsite spa, outdoor swimming pool and tennis court. There is also plenty of beach access on this private island. This adult-only resort is perfect for couples seeking a romantic escape.

Fort Zachary Taylor on the western coast of Key West is easily accessed by boat and makes for a great day trip with fabulous snorkelling, and features on my list of the best beaches in the Florida Keys.

Casa Marina Key West, Curio Collection by Hilton

A Waldorf Astoria resort and a member of the Curio Collection by Hilton, the 5-star Casa Marina Key West is one of the best luxury hotels in Key West.

The resort is located along South Beach and housed in a beautiful 1920s building with well-preserved Mediterranean architecture. All 311 guest rooms and 63 suites were newly renovated in spring 2024, and the hotel offers an expansive palm-fringed outdoor pool area.

There is also a private beach, fitness centre and pet friendly accommodations. Guests can also enjoy access to the amenities of the nearby sister property: The Reach Key West.

Simonton Court Historic Inn & Cottages

Offering a tropical boutique experience in the heart of the Key West Old Town, Simonton Court is an adults-only retreat housed in a selection of former cigar-making cottages.

Today they represent a luxury accommodation option in Key West, surrounded by tropical gardens. Spread over two acres, the resort offers a range of different cottages to suit all budgets. Amenities include four swimming pools, open 24 hours per day.

An interesting feature about Simonton Court is that the cottages are adorned with local artwork, all of which are available for guests to purchase. Duval Street and the Audubon House are both within walking distance of the resort.

Hyatt Centric Key West Resort & Spa

Located steps from the old part of Key West and Duval Street, the waterfront Hyatt Centric Key West Resort offers an unrivalled location in the city, with easy access to the beach and the city centre. They are also have a lot of accessibility features.

Rooms feature island-inspired décor and rainfall showers, and the hotel is also pet friendly. The onsite sea-to-table restaurant focuses on sustainability, serving a range of seasonal and fresh local ingredients. The resort also offers an outdoor swimming pool, fitness centre and the Jala Spa, where guests can enjoy a range of massages and therapeutic treatments.

The Mansion On The Sea

This adults-only boutique hotel, The Mansion on the Sea, formerly Southernmost House, is an historic beachfront property, built in 2897, and located at the far end of Duval Street, the Atlantic end, with fabulous views away from the tourists.

There are nine rooms in the main house, three bungalows and a full size apartment across Pocket Park, which would be ideal for a big group getaway or wedding guests. You can choose your room when you book, so know exactly what to expect. There is a beautiful pool and dining onsite at the Seaside Cafe, where lobster pizza and key lime pie is a must try.

Marrero’s Guest Mansion

Marrero’s Guest Mansion was originally private home. A massive Victorian house built in 1891 by prominent cigar maker, Francisco Marrero. It is now a gorgeous boutique hotel with modern renovations and wild pops of oranges and yellows, while keeping many of the historic architectural features.

Marrero’s is located about midway down Duval Street, so easy to walk to Mallory Square in one direction and Ernest Hemingway House in the other.

Each of the 12 guest rooms is individually designed with vibrant decor. Breakfast is included, there is a pool and daily happy hour at the onsite Tiki Bar.

Things to do in Key West

• Visit Eernest Hemingway’s House – and see the six-toed cats!
• Eat at Blue Heaven
• Stroll Duval Street
• Hit the golf course
• Visit the Key West Butterfly and Nature Conservatory
• Visit Key West Tropical Forest and Botanical Garden
• Walk through Downtown Key West
• Visit Mallory Square and the Key West Shipwreck Treasure Museum

For more ideas for things to do in Key West, I wrote this post.